Study links genetic rearrangement to obesity

I think we live in a fantastic age of medicine, and it will only get better with time. I’m so pleased to see the amount of research that is being done into obesity and our genes.

It makes me hopeful that one day, when a person says their weight is the cause of a medical condition a person won’t look at them sceptically. To this day, I still feel uncomfortable telling new people in my life about MC4r because I never know how they’re going to react.

I never know if they’re going to understand, or if they’re going to think I’m making excuses for my weight. It’s a genuine fear for me. I don’t want people to think I’m making excuses for “being lazy” or a “bad diet” and that’s just because I’ve gone most of my life with people thinking it’s okay to have an opinion on my lifestyle, even when they know nothing about it.

I’m sure there are many of you reading this, who know that feeling.

On that note, I’d like to talk about some new research in gene rearrangement that’s been linked to obesity in children.

The reason I want to talk about it is because, I like the idea that one day children may not have to be fearful of telling others they have medical condition that causes their weight problem – because of research like this.

The summaryread full article here.

A genetic rearrangement which is undetectable by most routine genetic tests, that leads to high levels of the agouti-signaling protein (ASIP), has been detected in five children with obesity. The initial study looked at one teenaged European girl who presented with sever obesity at the age of two, and a further four were identified after screening 1,700 children.

They concluded that genomic alterations resulted in the expression of ASIP and caused obesity phenotypes (the observable physical properties of an organism).

Naturally as it always does, this linked back to MC4r – we should all be familiar with this by now. There is plenty on the blog about it.

Researchers confirmed that genetic rearrangements in the testing sample warranted further screening into other patient groups, believing that their data concluded that the expression of ASIP is a likely cause of obesity.

Further research is needed to definitively link ASIP and obesity, and it’s link to MC4r.

The last few years have strongly indicated that rare mutations can impact human obesity, and it’s likely that more will be identified. However, they are still rare which means detection of these conditions needs to improve.

The article itself isn’t too long if you want to give it a proper read. I like to always give people the choice. I don’t want to get done for copyright or anything, I just tried to pull the highlights and take away some of the science jargon that I think might confuse people because even I had to Google a few things.

Overall, I’m always pleased to see new research. I do agree that detection needs to get better and I believe that starts with education. Which is why we’re here. So, if you’re reading this thank you and if you come to my blog regularly thank you.


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